Owen Wilson hosts Saturday Night Live on October 2, 2021, with musical guest Kacey Musgraves

Kim Kardashian West hosts Saturday Night Live on October 9, 2021 with musical guest Halsey

Rami Malek hosts Saturday Night Live on October 16, 2021 with musical guest Young Thug

Jason Sudeikis hosts Saturday Night Live on October 23, 2021 with musical guest Brandi Carlile

Kieran Culkin hosts Saturday Night Live on November 6, 2021 with musical guest Ed Sheeran

Jonathan Majors hosts Saturday Night Live on November 13, 2021 with musical guest Taylor Swift

Simu Liu hosts Saturday Night Live on November 20, 2021 with musical guest Saweetie

Billie Eilish hosts and performs as the musical artist. Kate McKinnon returns presenting the CDC Players

Actor and People's sexiest man of 2021 hosts

Ariana DeBose hosts Saturday Night Live on January 15, 2022 with musical guest Bleachers

Will Forte hosts Saturday Night Live on January 22, 2022 with musical guest Måneskin

Willem Dafoe hosts Saturday Night Live on January 29, 2022 with musical guest Katy Perry

John Mulaney hosts Saturday Night Live on February 26, 2022 with musical guest LCD Soundsystem

Oscar Isaac hosts Saturday Night Live on March 5, 2022 with musical guest Charli XCX

Zoë Kravitz hosts Saturday Night Live on March 12, 2022 with musical guest Rosalía

Jerrod Carmichael hosts Saturday Night Live on April 2, 2022 with musical guest Gunna

Jake Gyllenhaal hosts Saturday Night Live on April 9, 2022 with musical guest Camila Cabello

Lizzo hosts and performs as musical guest on Saturday Night Live on April 16, 2022

Benedict Cumberbatch hosts Saturday Night Live on May 7, 2022 with musical guest Arcade Fire

Selena Gomez hosts Saturday Night Live on May 14, 2022 with musical guest Post Malone

Natasha Lyonne hosts Saturday Night Live on May 21, 2022 with musical guest Japanese Breakfast